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4 edition of Principles of identifying and characterizing neurotoxicity found in the catalog.

Principles of identifying and characterizing neurotoxicity

Principles of identifying and characterizing neurotoxicity

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Published by U.S. Environmental Protection Agency in [Washington, D.C .
Written in English

    Subjects:
  • Neurotoxicology

  • Edition Notes

    StatementR.C. MacPhail
    ContributionsUnited States. Environmental Protection Agency
    The Physical Object
    FormatMicroform
    Pagination1 v
    ID Numbers
    Open LibraryOL13616194M
    OCLC/WorldCa29394114

    Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in. We then considered available methods of testing for neurotoxicity and evaluated strategies for recognizing and characterizing the neurotoxic potential of chemicals and for detecting neurotoxic effects among environmentally or occupationally exposed humans. Finally, we examined approaches to neurotoxicologic risk assessment.

    These principles cut across two dimensions of the scientific enterprise: the creativity, expertise, communal values, and good judgment of the people who “do” science; and generalized guiding principles for scientific inquiry. Neurotoxicity: Identifying and Controlling Poisons of the Nervous System control-oriented measures under CERCLA, – under Controlled Substances Act, economic incentives, features of laws, , under bad-Based Paint Poisoning Prevention Act, – under Marine Protection, Research, and Sanctuaries Act,

    When identifying bacteria in the laboratory, the following chatacteristics are used: Gram staining, shape, presence of a capsule, bonding tendency (singly or in pairs), motility, respiration, growth medium, and whether it is intra- or extracellular. X-ray diffraction (XRD) is the most extensively used method for identifying and characterizing various aspects of metals related to the arrangements and spacings of their atoms for bulk structural analysis. XRD techniques are also applicable to ceramics, geologic materials, and .


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Principles of identifying and characterizing neurotoxicity Download PDF EPUB FB2

HAZARD IDENTIFICATION Identification of neurotoxic chemicals refers to the screening of chemicals for neurotoxic potential.

There is currently considerable research in the development, validation and application of neurotoxicity screening meth- ods.

In general, screening methods should be sensitive, reliable, specific, efficient and by: 4. Get this from a library. Principles of identifying and characterizing neurotoxicity. [R C MacPhail; United States. Environmental Protection Agency.]. The Handbook of Neurotoxicity is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model.

The book has five sections. The first deals with general factors to be considered in the design of neurotoxicity studies and in the statistical analysis of their results. Experience acquired in the recent outbreaks of poisoning from methyl mercury and carbon disulfide are used to demonstrate both the importance of evaluating the neurotoxicity.

The Handbook of Neurotoxicity is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins Format: Hardcover ().

PRINCIPLES AND METHODS FOR THE ASSESSMENT OF NEUROTOXICITY ASSOCIATED WITH EXPOSURE TO CHEMICALS PREFACE • • • • • 1. INTRODUCTION 11 13 The importance of studying the nervous system 13 Methylmercury. • •. • 14 Carbon disulfide (CS2) • • • • July Toxicological Principles for the Safety Assessment of Food Ingredients Redbook Chapter IV.C Neurotoxicity Studies.

Return to Redbook table of contents. See the article "Methods to identify and characterize developmental neurotoxicity for human health risk assessment. II: neuropathology. " in volume Suppl 1 on Cited by:   Methods to identify and characterize developmental neurotoxicity for human health risk assessment.

III: pharmacokinetic and pharmacodynamic considerations. is companion of. Methods to identify and characterize developmental neurotoxicity for human health risk assessment: overview.

D C Dorman, S L Allen, J Z Byczkowski, L Claudio, J E Fisher Jr,Cited by: The Handbook of Neurotoxicity is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model 5/5(1).

Identification of the Endpoint for Neurotoxicity. Spectrum of Pathological Endpoint Detection. Study Design Principles: Location, Location, Location. Time Course for Observations of Neurotoxicity.

ReferencesCited by: 7. 1 Introduction: Defining the Problem of Neurotoxicity Neurologic Responses to Environmental Toxicants The human nervous system coordinates behavior; in perceiving and responding to external stimuli, it is responsible for mediating communication with the external environment; and it coordinates the activities of all other organ systems and thus plays an essential role in maintaining metabolic.

Book contents; Neurobehavioral Methods and Effects in Occupational and Environmental Health. Neurobehavioral Methods and Effects in Occupational and Environmental Health. Pages Assessing the Neurotoxic Potential of Chemicals—A Multidisciplinary Approach : George C.

Becking, William K. Boyes, Terri Damstra, Robert C. Macphail. Principles of identifying and characterizing neurotoxicity [microform] / R.C. MacPhail Neurotoxicology / edited by Kenneth Blum, Luigi Manzo Identifying and controlling poisons of the nervous system [microform]: hearing before the Subcommittee.

The final chapter examines the steps involved in neurotoxicity risk assessment: hazard identification, dose-response assessment, exposure assessment and risk characterization. The application of risk assessment principles for neurotoxicants is similar to that of other non-cancer end-points, except that issues of reversibility, compensation and Author: IPCS.

Part A: Guidelines for Neurotoxicity Risk Assessment 1. Introduction These Guidelines describe the principles, concepts, and procedures that the U.S.

Environmental Protection Agency (EPA) will follow in evaluating data on potential neurotoxicity associated with exposure to environmental toxicants. This includes characterizing their interactions with specific molecular targets and defining their pharmacokinetic and pharmacodynamic properties early in the clinical development process.

Pharmacokinetics is the analysis of drug absorption, distribution, metabolism, and excretion. 1 Often, a drug’s pharmacokinetic profile is summarized by a Cited by:   Principles of Neurobiology presents the major concepts of neuroscience with an emphasis on how we know what we know.

The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary by: Developmental neurotoxicity - Illustration of principles Article Literature Review in Pediatric Clinics of North America 48(5), ix November with 11 Reads How we measure 'reads'Author: Cynthia F Bearer.

This unique volume provides interdisciplinary coverage of the mechanistic perspective of neurotoxicity that focuses on the site of action of known neurotoxins. It provides the reader with an insight into the common characteristics of neurotoxin action on the nervous system and examines sites of action at three levels of complexity: molecular, celluCited by: 9.

Neurotoxicology of the Central Nervous System Introductory Overview, Louis W. Chang Introduction to Basic Principles of Neurocytology and General Concepts on Neurotoxicopathology, Louis W. Chang Blood-Brain and Blood-Nerve Barriers and Their Relationships to Neurotoxicity, Jean M.

Jacobs Receptors and Neurotransmitters in Neurotoxicity, Jerry M. Farley and Ing K. Ho The Role of Glia in .4 Neurotoxicity: Identifying and controlling poisons of the Nervous System number of neurotoxic substances in existence.

The number of substances that pose a signifi-cant risk to public health and the extent of that risk are unknown because the potential neurotoxicity of only a small number of chemicals has been evaluated adequately.ISBN: OCLC Number: Description: xviii, pages: illustrations ; 26 cm.

Contents: Neurotoxicology of the central nervous system --Introductory overview / Louis W. Chang --Introduction to basic principles of neurocytology and general concepts on neurotoxicopathology / Louis W. Chang --Blood-brain and blood-nerve barriers and their relationships .